Randomized Double-Blind Clinical Trials

In randomized, double-blind clinical trials of a new vaccine, subjects were randomly divided into two groups. Subjects in group 1 received the new vaccine while subjects in group 2 received a control vaccine. After the first dose, 104 of 707 subjects in the experimental group (group 1) experienced fever as a side effect. After the first dose, 60 of 610 of the subjects in the control ghroup (group 2) experienced fever as a side effect. Construct a 95% confidence intervalfor the difference between the two population proportions, P1 – P2. Construct a 95% confidence interval estimate.

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An interval estimate for the difference in proportions p_1 – p_2 with confidence level 1 – omega is given by

p_1 – …

The expert examines randomized double-blinds for clinical trails.